The McClung Lab

Department of Psychiatry

Translational Neuroscience Program

University of Pittsburgh Medical Center


Postdoctoral Fellowship:

2001-2003 University of Texas Southwestern Medical Center     

    Dr. Eric J. Nestler

    Dallas, TX                              



1995-2001 University of Virginia

    Dr. Jay Hirsh

    Charlottesville, VA               

    2001 Ph.D.  Biology


1990-1994 University of North Carolina          

    Chapel Hill, NC

    1994 B.S. Biology / Minor in Chemistry


2011-present      University of Pittsburgh Medical School

    Associate Professor - Pittsburgh, PA

2005-2011      UT Southwestern, Department of Psychiatry

    Assistant Professor - Dallas, TX

2003-2005      UT Southwestern, Department of Psychiatry

    Dr. Eric J. Nestler

    Assistant Instructor - Dallas, TX     

2001-2003      UT Southwestern, Department of Psychiatry          

    Dr. Eric J. Nestler

    Postdoctoral Fellow - Dallas, TX

1995-2001      University of Virginia, Department of Biology

    Dr. Jay Hirsh

    Ph.D. Thesis- Charlottesville, VA     

1994-1995      University of North Carolina, Department of Biology

    Dr. Dana Fowlkes/Dr. Brian Kay

    Research Technician - Chapel Hill, NC

1992-1994      University of North Carolina, Department of Biology

    Dr. Brian Kay

    Undergraduate Research - Chapel Hill, NC

1991-1994      University of North Carolina, Department of Biology

    Dr. Lillie Searles

    Laboratory Assistant - Chapel Hill, NC


1.  McClung C.A., Sidiropoulou, K., Vitaterna, M., Takahashi, J.S., White, F.J., Cooper, D.C. and Nestler, E.J. (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci USA 102 (26): 9377-9381.    

2.  Roybal, K., Theobold, D., DiNieri, J.A., Graham, A., Russo, S.J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., Vitaterna, M.H., Orsulak, P., Takahashi, J.S., Nestler, E.J., Carlezon, W.A. Jr., and McClung, C.A. (2007) Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA 104(15): 6406-6411.    

3.  Mukherjee, S., Coque, L., Cao, J-L., Kumar, J., Graham, A., Chakravarty, S., Asaithamby, A., Graham, A., Gordon, E., Enwright III, J.F., DiLeone, R., Birnbaum, S., Cooper, D.C., and McClung, C.A. (2010) Knock-down of CLOCK in the VTA through RNAi results in a mixed state of mania and depression-like behavior.  Biological Psychiatry 68: 503-511

4.  Dzirasa, K., Coque, L., Sidor, M., Kumar, S., Dancy, E.A., Takahashi, J.S., McClung, C.A., and Nicolelis M.A.L. (2010) Lithium reverses nucleus accumbens-phase timing dysfunction in Clock-19 mice.  Journal of Neuroscience 30: 16314-16323.  

5.  Dzirasa, K., McGarity, D.L., Bhattacharya, A., Kumar S, Takahashi, J.S., Dunson, D., McClung, C.A., and Nicolelis, M.A.L. (2011) Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania. Journal of Neuroscience 31: 6449-6456.  

6.  Coque, L., Mukherjee, S., Cao, J-L., Sidor, M., Spencer, S., Marvin, M., Falcon, E., Ozburn, A.R., Birnbaum, S.G., Graham, A., Neve, R.L., Gordon, E., Goldberg, M., Han, M-H., Cooper, D.C., and McClung, C.A. (2011) Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the Clock19 mouse model of mania.  Neuropsychopharmacology 36: 1478-1488.    

7.  Spencer, S.  Falcon, E., Kumar, J., Krishnan, V., Birnbaum, S.G., and McClung, C.A.  (2012) Circadian genes Period1 and Period2 in the nucleus accumbens regulate anxiety-related behavior. European Journal of Neuroscience, 37: 242-250.  

8. Arey, R., Enwright III, J.F., Spencer, S., Falcon, E., Ozburn, A.R., and McClung, C.A. (2013) An important role for Cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.  Molecular Psychiatry, 19: 342-350.

9. Ozburn, A.R., Falcon, E., Mukherjee, S., Gillman, A., Spencer, S., Arey, R.N., and McClung, C.A.  (2013) The Role of Clock in Ethanol Related Behaviors.  Neuropsychopharmacology, 38: 2393-2400.    

10. Ozburn, A.R., Falcon, E., Twaddle, A., Nugent, A.L., Gillman, A.G., Spencer, S.M., Arey, R.N., Mukherjee, S., Lyons-Weiler, J., Self, D.W., and McClung, C.A. (2014) Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2.  Biological Psychiatry, in press.  *Selected as a priority communication.  

11. Sidor, M.M., Spencer, S., Dzirasa, K., Parekh, P.K., Tye, K.M., Warden, M.R., Arey, R.N., Enwright III, J.F., Jacobsen, J.P.R., Kumar, S., Remillard, E.M., Caron, M.G., Deisseroth, K., and McClung, C.A. (2015) Daytime spikes in dopaminergic activity underlie rapid mood-cycling.  Molecular Psychiatry, 20:1479-80. 


12. Logan, R.W., Edgar, N., Gillman, A.G., Hoffman, D., Zhu, X., and McClung, C.A. (2015) Chronic stress induces brain region specific alterations of molecular rhythms in mice that correlate with depression-like behavior.  Biological Psychiatry, 78: 249-58. 


13. Chen, C.Y., Logan, R.W., Tianzhou, M., Lewis, D.A., Tseng, G.C., Sibille, E., and McClung, C.A. (2016) The effects of aging on circadian patterns of gene expression in the human prefrontal cortex.  Proc Natl Acad Sci, USA, 113:206-11. 


14. Parekh, P.K., Becker-Krail, D., Sundaravelu, P., Ishigaki, S., Okado, H., Sobue, G., Huang, Y., and McClung, C.A. Altered GluA1 function and accumbal synaptic plasticity in the ClockD19 model of bipolar mania.  Biological Psychiatry, in press 

Colleen A. McClung, Ph.D.